One problem you'll encounter if you use OSGB is that when you're doing a multicache you'll be getting new co-ordinates in lat/long as you go along, and if you want to work entirely with OSGB you'll need some means of converting them out in the field. With most gps units, though, you can readily switch between OS grid references and lat/long, but remember to also change the datum, which should be WGS84 for lat/long and OSGB36 for OS grid refs, unless your gps does that automatically.
Do not go gentle into that good night.
Rage, rage against the dying of the light. (Dylan Thomas)